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  • Assoc.Prof. Joseph Olobo
PROF.JOSEPH OLOBO(MICROBIOLOGY AS PROFESSOR)

Assoc. Prof. Joseph Olobo

Professor

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Assoc. Prof. Joseph Olobo Okao

  • Professor
  • oloboj@yahoo.co.uk / joloboj2@gmail.com
  • +256-772-613620/751-613620

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Education & Qualifications
  1. PhD, Immunobiology, 1987; University of Nairobi (Studies conducted at; International Laboratory for Research on Animal Diseases, (ILRAD now “ILRI”). Dissertation: “Studies towards generation of cell lines as fusion partners for intraspecies bovine monoclonal antibody production”.
  2. Master of Science, Immunoparasitology; 1979, University of Nairobi, Dissertation in partial fulfillment of the degree: “The role of antibodies in experimental Trypanosoma congolense infection in rats”.
  3. Bachelor of Veterinary Medicine,1975; University of Nairobi.

        Past

  • Member of the Kenya Veterinary Association
  • Member of the East African Society of Parasitologists
  • Member of the African Association of Insect Scientists
  • Member of the East African Wildlife Society
  • Member of American Association for the Advancement of Science
  • Member of the Royal Society of Tropical Medicine and Hygiene
  • Member of the Kenya Society for Immunology
  • Member of the New York Academy of Sciences
  • Member of the Biological Society of Ethiopia
    Current
  • Member of Uganda Society for Health Scientists- 2007-to date
  • Member of Uganda Veterinary Association-2009-to date
  • Member of the Association of African Immunological Societies-1994-to date
  1. OLOBO, J.O., Handman, E., Curtis, J.M. and Mitchell, G.F. (1980). Antibodies to L.tropica promastigotes during infection in mice of various genotypes. The Australian Journal of Experimental Biology and Medical Science, 58: 595
  2. OLOBO, J.O. and Mutinga, M.J. (1982). Partial protection of rats against T.congolense by passive transfer of serum IgM. Veterinary Parasitology 11: 261
  3. OLOBO, J.O. and Mutinga, M.J. (1983). Uptake of promastigotes of a lizard Leishmania sp. and Leishmania donovani by mouse peritoneal macrophages. Acta Tropica 40: 89
  4. Mutuku, J., Mutinga, M.J., John, B. Kaddu, OLOBO, J.O., Francis M. Kyai (1983). Studies on vectors of kala-azar in Kenya. Phlebotomusheischi(Diptera, Psycodidae) Kirk & Lewis. A new male record in Kenya. Insect Sci. Applications 4(3): 253-4
  5. OLOBO, J.O. and Black, S.J. (1989). In vitro secretion of bovine immunoglobulins during pokeweed mitogen and antigen activation of lymphocytes. Vet. Res. Commun. 13: 193
  6. OLOBO, J.O. and Black S.J. (1989). Phenotypic and cloning properties of a bovine lymphoblastoid cell line BL20. Vet. Immunol. Immunopath, 20: 165
  7. OLOBO, J.O. and Black, S.J. (1990). Generation of bovine intraspecies hybridomas with initial suppressed growth. Vet. Immunol. Immunopath 24: 293
  8. OLOBO, J.O.and Reid, G.D.F. (1990). Mitogenic responses of peripheral blood mononuclear cells of vervet monkeys (C. aethiops): Apparent role of adherent cells. Amer. J. Primatology. 20: 31
  9. Lawyer, P.G., Githure, J.I. Anjili, C.D., OLOBO, J.O.,Koech, D.K. and Reid, G.D.F. (1990). Experimental transmission of Leishmania major to vervet monkeys (Cercopithecus aethiops) by bites of Phlebotomus duboscqi (Dipterapsychodidae). Trans. Roy. Soc. Trop. Med. Hyg. 84: 229
  10. Davy K. Koech, JOSEPH O. OLOBO, Alex Wamachi, John I. Githure and Graham D.F. Reid (1992). Cellular responses of vervet monkeys (Cercopithecus aethiops) experimentally infected with L. major. J. Med. Primatol. 21: 375
  11. OLOBO, J.O. (1992). Reactivity of some monoclonal antibodies specific for human lymphocytes with the vervet monkey peripheral blood mononuclear cells. Scand. J. Immunol. 36 Suppl. 11, 199
  12. OLOBO, J.O., Reid, G.D.F., Githure, J.I., Anjili, C.O. (1992). IFN- and delayed-type hypersensitivity are associated with cutaneous leishmaniasis in vervet monkeys following secondary rechallenge with Leishmania major. Scand. J. Immunol. 36, Suppl. 11, 48
  13. Binhazim, A.A., Shin, S.S., Chapman, W.L. and OLOBO, J.O. (1993). Comparative susceptibility of African Green Monkeys (Cercopithecus aethiops) to experimental infection with Leishmania donovani and Leishmania infantum. Laboratory Animal Science: 43(1): 37
  14. OLOBO, J.O. and Reid, G.D.F. (1993). Delayed-type hypersensitivity responses in vervet monkeys self-cured from cutaneous leishmaniasis. Acta Tropica, 52(4): 309
  15. Allison, J.C., Jardim, A., OLOBO, J.O. and Olafson, R.W. (1994). Cell-mediated responses of immunisedvervet monkeys to defined Leishmania T-cell epitopes. Infection and Immunity, 62(5): 1733-17416
  16. Gicheru, M.M. and OLOBO, J.O. (1994). Evaluation of recombinant gp63, the major Leishmania surface glycoprotein, as a diagnostic molecule for leishmaniasis in vervet monkeys. Acta Tropica, 58: 345-348
  17. Anjili, C.O., OLOBO, J.O., Mbati, P.A., Robert, L. and Githure, J.I. (1994). Experimental infection of domestic goats with Leishmania major through bites of Phlebotomus duboscqi and needle inoculation of culture-derived promastigotes. Vet. Res. Commun. 18: 301-305
  18. OLOBO, J.O.,Anjili, C.O., Githure, M.M., Mbati, P.A., Kariuki, T.M., Koech, D.K. and McMaster, W.R. (1995). Vaccination of vervet monkeys against cutaneous leishmaniasis using recombinant Leishmania major surface glycoprotein (gp63). Vet. Parasitol. 60:199-212.

Missing…

  1. MRC Collaborating Grant (2020-2025): Characterizing the influence of parasite variation on visceral leishmaniasis. ROLE; PI
  2. PREV_PKDL Study: EDCTP Collaborative project- (2018-2025): Clinical development of a therapeutic vaccine for prevention of post kala azar dermal leishmaniasis. A multicentre observational study to assess immune response status in patients before and after treatment for visceral leishmaniasis ROLE; PI
  3. African leishmaniasis: from clinical research to access (Leish Access). EDCTP Collaborative project- (2020-2024). ROLE; PI
  4. AfricaDIA-VLDXEAFR Study: EDCTP Collaborative project- (2018-2021): Evaluation of antibody detection tests for visceral leishmaniasis diagnosis in eastern Africa. ROLE; PI
  5. World Bank Grant. (2017-2022): Center for innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Science, Addis Ababa University and Makerere University College of Health Sciences. Role; PARTNER.
  6. PM Miltefosine (MF.PM Study): Collaborative project- (2018-2022): An open label, phase III, randomized, controlled, parallel arm multicenter non-inferiority clinical trial to compare the efficacy of two combination regimens of miltefosine and paromomycin with the standard SSG-PM for the treatment of primary adult and children VL patients in Eastern Africa. ROLE; PI
  • Otieno, L.H., Darji, N., OLOBO, J.O. and Onyango, P. (1980). The efficiency of Wild Glossina pallidipes austenias vectors of pathogenic African trypanosomes In: Isotope and Radiation Research on Animal Diseases and Their Vectors, Proceedings of Symposium held in Vienna, Austria.
  • OLOBO, J.O., Koech, D.K. and Reid, G.D.F. (1988). Cellular immunity of vervet monkeys following experimental infection with L. major. In proceedings: WHO/TDR Workshop on Vaccine Development in Primates, Nairobi, Kenya
  • Lawyer, P.G., Githure, J.I., Anjili, C.D., OLOBO, J.O., Koech, D.K. and Reid, G.D.F. (1988). Experimental transmission of Leishmania major to vervet monkeys (Cercopithecus aethiops) by bites of Phlebotomus duboscqi (Dipetra: Psychodidae). Proc. 10th Ann. Med. Conf. KEMRI/KETRI – Nairobi
  • Reid, G.D.F., OLOBO, J.O., Githure, J.I., Koech, D.K. and Anjili, C. (1990). Immunisation of primates against L. major. In proceedings UNDP/WORLD BANK/WHO Workshop on “Vaccine against Leishmaniasis”. Belo Harizonte, Brazil
  • Anjili, C.O., OLOBO, J.O., Mbati, P., Githure, J.I., Reid, G.D.F., and Koech, D.K. (1992). Evaluation of the optimum dose of culture derived Leishmania major promastigotes required to assess the immune status of vervet monkeys. In Proceedings of Medical Scientific Conference of KEMRI/KETRI
  • OLOBO, J.O., Anjili, C.O., Githure, J.I., Koech, D.K., Lawyer, P. and Reid, G.D.F. (1992). Experimental cutaneous Leishmaniasis in the vervet monkey (Cercopithecus aethiops): Cellular responses following self-cure (In Proceedings of Medical Scientific Conference of KEMRI/KETRI
  • OLOBO, J.O., Reid, G.D.F., Githure, J.I., Anjili, C.O., Koech, D.K. (1992) The vervet monkey model for human cutaneous leishmaniasis. In Proceedings of XIVth Congress of Int. Primatol. Society, StrasbourgFrance 16 – 21 Aug.
  • OLOBO, J.O. and Githure, J.I. (1993). A model for anti-Leishmania vaccine and drug development. In Proceedings: Acta Microbiologica et imunologica Hungarica 41(1): 102 11
  • Lonsdale-Eccles, J.D., Mpimbaza, G.W.N., Nkhungulu, Z.R.M., OLOBO, J.O. and Grab, D.J. (1994). A kininogen moiety modulates trypanosomatid cysteine protease activity. In Proceedings: Experimental Biology 94
  • O’Hara, H., Wango, E.O., Tumbo-Oeri, A.G., Schwoebel, E., OLOBO, J.O. and Isahakia, M. (1994). Immunohistochemical localization of Pan-B and Pan-T lymphocytes in the female genital tract of the baboon (Papio anubis) during the menstrual cycle (In: Proceedings of the 2nd African Immunological Conference of the Federation of African Immunological Societies, Nairobi, Kenya 23-27th Oct.
  • Gicheru, M.M., OLOBO, J.O., Kariuki, T.M. and Adhiambo, C. (1994). Visceral leishmaniasis in Vervet Monkeys: Immunological responses during asymptomatic infections (In: Proceedings of the 2nd African Immunology Conference of the Federation of African Immunological Societies, Nairobi, Kenya, 23-27 Oct.
  • Ozwara, H.S., OLOBO, J.O. and Irungu, L.W. (1994). Evaluation of immune associated cell types in lesions of vervet monkeys (Cercopithecus aethiops) experimentally infected with Leishmania major (In: Proceedings of the 2nd African Immunology Conference of the Federation of African Immunological Societies, Nairobi, Kenya 23-27 Oct.
  • Kavihya-Ndugga, L., OLOBO, J.O., Aluvaala, B., Makawiti, D. and Gathua, S. (1994) Cytokine profiles in tuberculosis (In: Proceedings of the 2nd African Immunology Conference of the Federation of African Immunological Societies, Nairobi, Kenya, 23-27 Oct.
  • Participant in the WHO collaborative study for IL-3 and IL-4 organised by Dr Anthony R. Mire-Sluis from the International Laboratory for Biological Standards and Control, U.K. Results of the study have been published.
  • OLOBO, J.O., Gicheru, M.M., Kariuki, T.M., Ozwara, H.S., Anjili, C.O., Mbati, P.A., Githure, J.I., Lawyer, P.J., Koech, D.K., McMaster, R., Beverley, S., Scott, P.1996. Primate studies: Trials of first and second-generation leishmanial vaccines. Proceedings of clinical Trials of Killed Leishmania major vaccine. Amman, Jordan, 15-16th, 1996.